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03/24/2023
Consistent ANOVA-type tests for various effect sizes
Analysis of variance (ANOVA) reveals some disadvantages, such as non-rob...
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03/16/2023
The Dunnett procedure with possibly heterogeneous variances
Most comparisons of treatments or doses against a control are performed ...
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02/11/2023
The Kruskal Wallis test can not be recommended
Although the Kruskal-Wallis (KW) test is widely used, it should not be r...
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05/31/2022
Seven recommendations for alternatives to the common analysis of variance (ANOVA) with application in the life sciences – using R
Standard ANOVA is among the most widely used tests in the life sciences ...
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03/28/2022
Simultaneous confidence intervals for the interpretation of primary and secondary effects in factorial designs without a pre-test on interaction
The analysis of low dimensional factorial designs with possible interact...
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01/08/2022
Evaluation of histological findings with severity grade, to analyze toxicology in-vivo studies
In-vivo toxicological studies are characterized by multiple primary endp...
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11/15/2021
Simultaneous inference of correlated marginal tests using intersection-union or union-intersection test principle
Two main approaches in simultaneous inference are intersection-union tes...
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03/13/2021
Closed testing procedures for treatment-versus-control comparisons and multiple correlated endpoint
Preferably in two- or three-arm randomized clinical trials, a few (2,3) ...
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03/11/2021
Simultaneous comparisons of treatments versus control (Dunnett-type tests) for location-scale alternatives
Commonly, the comparisons of treatment groups versus a control is perfor...
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01/02/2021
A statistical method for estimating the no-observed-adverse-event-level
In toxicological risk assessment the benchmark dose (BMD) is recommended...
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12/30/2020
Closed test procedures for the comparison of dose groups against a negative control group or placebo
Dose groups are compared with a control assuming an order restriction us...
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12/08/2020
Comparisons of multiple treatment groups with a negative control or placebo group: Dunnett test vs. closed test procedur
Several treatments are usually compared with a control using the Dunnett...
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11/27/2020
Comparisons of proportions in k dose groups against a negative control assuming order restriction: Williams-type test vs. closed test procedures
The comparison of proportions is considered in the asymptotic generalize...
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11/10/2020
Statistical evaluation of in-vivo bioassays in regulatory toxicology considering males and females
The separate evaluation for males and females is the recent standard in ...
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09/25/2020
Similarity of multiple dose-response curves in interlaboratory studies in regulatory toxicology
To claim similarity of multiple dose-response curves in interlaboratory ...
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07/24/2020
A versatile trend test for the evaluation of tumor incidences in long-term carcinogenicity bioassays
For the evaluation of carcinogenicity bioassays a new trend test is prop...
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07/22/2020
Model-based simultaneous inference for multiple subgroups and multiple endpoints
Various methodological options exist on evaluating differences in both s...
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07/19/2020
Claiming trend in toxicological and pharmacological dose-response studies: an overview on statistical methods and related R-Software
There are very different statistical methods for demonstrating a trend i...
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07/08/2020
A Tukey type trend test for repeated carcinogenicity bioassays, motivated by multiple glyphosate studies
In the last two decades, significant methodological progress to the simu...
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06/26/2020
A modified Armitage test for more than a linear trend on proportions
The Armitage test for linear trend in proportions can be modified using ...
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05/06/2019