Few-Shot Microscopy Image Cell Segmentation
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Automatic cell segmentation in microscopy images works well with the support of deep neural networks trained with full supervision. Collecting and annotating images, though, is not a sustainable solution for every new microscopy database and cell type. Instead, we assume that we can access a plethora of annotated image data sets from different domains (sources) and a limited number of annotated image data sets from the domain of interest (target), where each domain denotes not only different image appearance but also a different type of cell segmentation problem. We pose this problem as meta-learning where the goal is to learn a generic and adaptable few-shot learning model from the available source domain data sets and cell segmentation tasks. The model can be afterwards fine-tuned on the few annotated images of the target domain that contains different image appearance and different cell type. In our meta-learning training, we propose the combination of three objective functions to segment the cells, move the segmentation results away from the classification boundary using cross-domain tasks, and learn an invariant representation between tasks of the source domains. Our experiments on five public databases show promising results from 1- to 10-shot meta-learning using standard segmentation neural network architectures.
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